31, July 2025

Antioxidant, anti-arthritic and anti-inflammatory activity of methanolic extracts of Cardiospermum halicacabum seeds

VOLUME-11; ISSUE-7; JULY-2025

Author(s): Caroline Hema , J. Vinoliya Josephine Mary, Umerali Kunnakkadan, S. Mary Mettilda Bai, John.B.Johmson

Authors Affiliations:

1Research Scholar (19223042192022) Department of Zoology, Holy Cross College (Autonomous), Nagercoil. Affiliated to Manonmaniam Sundaranar University, Tirunelveli, Tamil Nadu, India. (vcaroline1979@gmail.com).

2,4Associate professor, Department of Zoology, Holy Cross College (Autonomous), Nagercoil, Affiliated to Manonmaniam Sundaranar University, Tirunelveli, Tamil Nadu, India.

3,5 Pathogen Biology, Virology, BRIC-Rajiv Gandhi Center for Biotechnology, Thiruvananthapuram, Kerala, India.

2*vinoliya75@gmail.com, 3marymettildabai@holycrossng.edu.in

DOIs:10.2015/IJIRMF/202507050     |     Paper ID: IJIRMF202507050


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Abstract

Cardiospermum halicacabum L., belonging to the family Sapindaceae is a traditional medicinal plant commonly known as balloon vine. Bioactive compounds such as flavonoids, saponins, triterpenes  and phenolic acids, which contribute to a wide range of pharmacological activitieshas been reported from seeds. This study investigates the antioxidant, antiarthritic and anti-inflammatory properties of C. halicacabum seed extract. Antioxidant activity was evaluated using DPPH and hydroxyl radical scavenging assay, demonstrating strong radical scavenging potential. The antiarthritic effects assessed through protein denaturation and anti-inflammatory activity by LOX and COX assays revealed significant inhibition of inflammatory mediators. Dose-dependent responses were noted, with higher extract concentrations showing enhanced activity across all tested parameters. Comparative analysis with standard drugs indicated that the extract had comparable efficacy. The results suggest that C. halicacabum seed extract can modulate oxidative and inflammatory pathways involved in arthritis pathogenesis. The findings validate the ethnomedicinal use of C. halicacabum seeds in the treatment of inflammatory and arthritic conditions and suggest their potential as a natural therapeutic source for oxidative and inflammatory disorders.

Keywords: Cardiospermum halicacabum, seed extract, antioxidant, antiarthritic, anti-inflammatory, Sapindaceae

Caroline Hema , J. Vinoliya Josephine Mary, Umerali Kunnakkadan, S. Mary Mettilda Bai, John.B.Johmson (2025); Antioxidant, anti-arthritic and anti-inflammatory activity of methanolic extracts of Cardiospermum halicacabum seeds, International Journal for Innovative Research in Multidisciplinary Field, ISSN(O): 2455-0620, Vol-11, Issue-7, Pp. 343-341         Available on –   https://www.ijirmf.com/

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