20, June 2025

Molecular Mechanisms Underlying Hypertriglyceridemia and Its Role in Cardiovascular Disease

VOLUME-11; ISSUE-6; JUNE-2025

Author(s): Jharna Maiti

Authors Affiliations:

Department of Biochemistry, Kalinga University, Naya Raipur (C.G.) 492101

DOIs:10.2015/IJIRMF/202506007     |     Paper ID: IJIRMF202506007


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Abstract:    Hypertriglyceridemia, marked by elevated blood triglyceride levels, is increasingly recognized as a key contributor to cardiovascular disease. Triglyceride-rich lipoproteins (TRLs) and their remnants promote atherogenesis through endothelial dysfunction, inflammation, and oxidative stress. Molecular disruptions involving lipoprotein lipase (LPL), apolipoprotein C-III (ApoC-III), and angiopoietin-like proteins (ANGPTLs) impair lipid metabolism and lead to the accumulation of atherogenic particles. This review highlights the mechanistic pathways linking hypertriglyceridemia to cardiovascular risk and explores emerging therapeutic strategies targeting these molecular drivers.

     
Key Words:  Hypertriglyceridemia, Triglyceride-rich lipoproteins (TRLs), Lipoprotein lipase (LPL), Apolipoprotein C-III (ApoC-III), Angiopoietin-like proteins (ANGPTLs)

Jharna Maiti (2025); Molecular Mechanisms Underlying Hypertriglyceridemia and Its Role in Cardiovascular Disease, International Journal for Innovative Research in Multidisciplinary Field, ISSN(O): 2455-0620, Vol-11, Issue-6, Pp.50-55.          Available on –   https://www.ijirmf.com/

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