INTERNATIONAL JOURNAL FOR INNOVATIVE RESEARCH IN MULTIDISCIPLINARY FIELD

Abstract:    Actinic prurigo (AP) is a chronic, idiopathic photodermatosis marked by intensely itchy, symmetrical papulonodular eruptions predominantly on the sun-exposed face, neck, and arms. However, sun-protected regions may also be affected. It typically appears in spring but can persist year-round and may cause excoriations, cheilitis, ocular damage, and scarring. AP affects individuals of all ages and genders, with a strong genetic predisposition, especially among Indigenous populations in the Americas, and is frequently associated with HLA-DR4 alleles. The condition results from abnormal immune responses to UV radiation. Diagnosis is mainly clinical but may be supported by histopathology. Management includes rigorous sun protection, high-SPF sunscreen, and protective clothing. First-line treatments involve topical corticosteroids and antihistamines, while severe or refractory cases may need photochemotherapy or systemic agents like thalidomide or antimalarials. Early diagnosis and individualized treatment are essential to prevent long-term complications and improve patient outcomes.